Saturday, 2 February 2013

The Pathophysiology of Eczema and Psoriasis

This paper has been suggested by one of my esteemed colleagues:

http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2230.2005.01980.x/pdf

Allam and Novak's "the Pathophysiology of Eczema" discusses the processes behing eczematic inflammation. It is particularly good for a review of acute chemotaxis and the underlying chemical messengers and cell activity.

Specifically for eczema, the section on genetics places the disease in the context of malfunctioning immune response. The paper is also pleasingly succinct, with a very nice image AND there is a very medical student-friendly summary at the end as learning points.

And as a nice counterpart, while you are in the mood for dermatology and immunology.

http://ard.bmj.com/content/64/suppl_2/ii30.full.pdf+html

Krueger and Bowcock's "Psoriasis Pathophysiology: Current concepts of pathogenesis" is more dense than Allam and Novak, and a bit turgid to begin with, but assumes very little knowledge of immune cells. It contains a lot of transferable knowledge. There is more genetics than anyone could possibly need, but as with Allam and Novak, the immunology is well described and as all good papers do, it has a great big diagram with arrows in it.

Sit down with a coffee and try to work through these papers when studying atopy or dermatology - it will be very rewarding.
Good learning,

Marblecake

No comments:

Post a Comment