Restless legs syndrome: pathophysiology, clinical presentation and management.

Summary:
Restless leg syndrome (RLS) is common; estimated prevalence is 1/10. The symptoms can be debilitating, but are usually mild. "URGE" is an acronym for the 4 key symptoms: urge to move, rest aggravates, getting active relieves, evening and night is worse. Only some people are troubled enough to require treatment, but at that point complexity starts. Both iron supplements and dopamine agonists benefit the majority of patients. Yet numerous underlying conditions may explain RLS. What follows is an exploration of a problem with metabolic, genetic and neurological causes.

Link:
Restless legs syndrome: pathophysiology, clinical presentation and management.
or PDF

Key points explored:
What are the essential diagnostic features of RLS?
What roles do Iron, Dopamine and genetics have in RLS pathogenesis?
What underlying diagnoses should be considered, and how should patients be managed?
How does RLS relate to other movement disorders, like parkinsonism?