Saturday, 28 September 2013

Psychogenic disorders - somatisation, conversion, malingering and facticious disorders

Psychogenic disorders are very common, but attract a proportionally tiny spot in medical education and in research budgets. Much clinical time and resources are used mistreating people with these conditions. Stigma is common, and doctors talk of 'real' and 'not real' symptoms; such judgements are more a reflection of medical ignorance than ability to see into the patient's mind.
Stigma probably arises from the patients being difficult, and the doctors being impotent to manage them.
A key distinction used in diagnostic manuals is between voluntary disorders (factitious and malingering) versus involuntary ones (conversion and sanitisation). However these distinctions are largely inadequate  outside of conceptual distinctions, because they rely on mind reading.
Mind body dualism abounds in all these discussions, with references to "psychological or neurological", or "in the mind or a real disease". Perpetuating those dualist throwbacks are an obstacle to the patient's recovery: giving patients clear and accurate information on their condition improves their outcome substantially. Saying "your condition doesn't have a known cause other than stress and emotion" validates the condition whilst being honest. To often clinicians will feign from discussion, perhaps not knowing what to say. But patients are reliant on clear advice from doctors in order to engage in their treatment and improve.
The plot thickens when we consider that existing neurological disease can be fuel for an psychogenic predisposition, resulting in one disease's symptoms being exaggerated or morphed from recognition.
A shift is required in how we perceive the psychological dimensions of illness, and to be compassionate toward them.

Psychogenic DisordersThe Need to Speak Plainly



Sugar, will and cognitive performance

It is a common folk psychology belief that eating or drinking something carbohydrate rich will benefit performance in concentration, study or work. This phenomena was recently examined in a small but well designed study, with similarities to the placebo-balanced design as popularised by researchers like Fabrizio Benedetti.
The explicit hypothesis is that a view that willpower is limited and can be replenished with sugar will be a self fulfilling prophecy, whilst an unlimited model of willpower will lead to neutral responses to sugar.
This study is essentially about placebo effects of sugar, and suggests that our beliefs about energy, willpower and carbohydrates shape our cognitive responses.
The authors make the commendable point that we can be liberated from dependency on health ruining foods and drinks in the hope of performing better.

Key points:
  • Existing beliefs that willpower is unlimited correlate with no response to sugar on cognitive tasks
  • Actual consumption of sugar has different effects to the taste of sweetness, or the belief it is sugar.
  • Beliefs can be modified quickly and exert effects on response to sugar.
  • The performance enhancement form glucose is in part due to socially perpetuated beliefs that willpower is limited, deplete-able and replenished with sugar.


Beliefs about willpower determine the impact of glucose on self-control
Veronika Joba,1, Gregory M. Waltonb, Katharina Berneckera, and Carol S. Dweckb,1

Tuesday, 17 September 2013

fMRI and BOLD - what do the pretty lights actually mean?

Functional magnetic resonance imaging (fMRI) relies on the blood oxygen level dependent signal (BOLD). fMRI is best known for pretty pictures of brains with lights on certain bits, which incidentally are often of little utility for medicine or science due to poor study design (see Uttal).
This paper goes from basics to advanced and is well worth a read if interested in the edge of current controversy.
Key points:

  • BOLD signal arises from the relative overshoot in blood supply to increasing metabolic activity, leading to higher Oxy-haemoglobin, which is detected in venules.
  • The most metabolically demanding activity in neurons is maintenance of resting potentials
  • Glia are also metabolically active
  • Local field potentials (LFPs) are probably the greatest cause of metabolic activity, and correlate strongly with BOLD in monkey experiments
  • Neuronal action potentials (APs) have varying correlation with BOLD in monkey experiments, which may depend on when LFPs correlate with AP rates
  • Different brain regions have different relationships between LFPs and AP rates; i.e hippocampus shows dissociation
  • Dissociation can, theoretically, occur because of circuitry and vascular phenomena
Paper: